ATP1000馬德里大師賽爆出大冷門，繼德約科維奇首秀出局外，衛冕冠軍盧布列夫苦戰三盤以1-2不敵布勃利克，三盤比分為4-6/6-0/4-6。上一輪，盧布列夫收獲了賽前的退賽大禮，本場比賽是他的馬德里首秀。雖然次盤送出一顆“夾心蛋”，但仍難挽敗局。

比賽期間，盧布列夫情緒失控，再度出現暴怒摔拍的“名場面”，就連新合作的教練薩芬也是對此毫無辦法，只能扶著頭苦笑。這一幕出現在決勝盤盧布列夫自己的發球局，雙誤被破發，氣急敗壞之下摔了拍子。輸掉此役后，盧布列夫排名跌出前十，即時排名降至第17位，連續137周世界前十的紀錄就此終結，距離他在TOP10開外還是2022年9月5日。

進入紅土賽季，盧布列夫為了能夠重回巔峰，選擇了和前世界第一薩芬合作，結果3站比賽都沒有取得好成績。蒙特卡洛1勝1負闖入第三輪、巴塞羅那1勝1負晉級到第二輪、馬德里0勝1負入圍第三輪（首輪輪空、第二輪孟菲爾斯賽前退賽）。

頭號種子茲維列夫則是拒絕爆冷，他以2-1險勝達維多維奇·弗基納晉級。首盤，茲維列夫開場連丟4局，以2-6輸掉首盤；第二盤，茲維列夫在次盤第9局驚險化解兩個破發點，以7-6(3)扳回；第三盤，茲維列夫搶七局連拿7分，以7-6(0)獲勝，連續8屆賽事均打進16強。

本場比賽，茲維列夫還效仿斯圖加特站的薩巴倫卡，對于裁判的判罰表達不滿，并拿手機拍照而遭到警告。這一幕出現在弗基納局分4-5落后的發球局第一分，對手的一次網前推底線被電子線審判定為壓線，茲維列夫強烈要求主裁下場查看球印，但按規定主裁得以電子線審的判定為準，所以茲維列夫只能拿出手機拍下球印，好在這一分并沒有影響到茲維列夫。

隨著最后一名西班牙本土球員維多維奇·弗基納的出局，西班牙軍團在馬德里賽遭遇滑鐵盧，創下09年以來的最差戰績，他們不管是男球員還是女球員，都無人晉級16強。去年八強阿爾卡拉斯退賽、去年16強納達爾退役、去年16強托莫暫別網壇、2013年16強巴多薩退賽；本屆馬德里，阿爾卡拉斯和巴多薩兩位一哥一姐也都因傷退賽。
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