Thieme Cheminar #40

Thieme Chemistry Journal Awardees

本期特別研討會特邀2024年Thieme Chemistry Journal Award獲獎者參與，由南方科技大學講席教授、Synthesis中國區副主編劉心元教授主持。

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Thieme Cheminar

2025年07月17日 周四

16:00 - 18:20北京時間

識別二維碼觀看直播

直播鏈接：http://live.bilibili.com/23843035

演講嘉賓和主題

Thieme Cheminar

主持人

劉心元 教授

南方科技大學

# 1

Systems Chemistry of polymer nanoparticles

Dr. Stephen Fielden

伯明翰大學

Contemporary methods of polymerization have made it possible to construct sequence polymers, including block copolymers, with high precision. These copolymers can be designed to assemble in solution and produce nano- and microparticles of various shapes and sizes. Such assembly often occurs under kinetic control, meaning particles are formed in a nonequilibrium state. This leads to a rich variety of behaviours being observed in block copolymer assemblies, such as pathway dependence (e.g., thermal history), nonergodicity and responsiveness.

In this talk I will present several studies concerning polymer assemblies. These include the kinetically controlled hetero-fusion between two populations of unfunctionalised nanoparticles. Here, fusion extent can be tuned simply by adjusting polymer length. We probed fusion using an elemental tag for cryogenic scanning transmission electron microscopy combined with electron energy loss spectroscopy (cryo-STEM-EELS). Our results demonstrate emergence of a complex process when populations of synthetic nanoparticles are combined. We anticipate systems-level behaviour that results from such processes will be fashioned as an elementary mechanism of synthetic communication that enables future materials and technologies.

# 2

Sulfoxylate as a Redox Activator for Photoinduced Generation of Ketyl Radicals from Carbonyls

Dr. Adam Noble

布里斯托大學

Ketyl radicals are valuable intermediates that allow carbonyl chemistry to be extended beyond traditional electrophilic reactivity. However, accessing them by single-electron reduction of carbonyls requires strongly reducing conditions. This talk will focus on our development of an alternative strategy to access ketyl radicals from aldehydes that avoids the reduction pathway, instead proceeding via single-electron oxidation and desulfination of in situ-generated α-hydroxy sulfinates.

# 3

Merging H-bond donors and gold(I) catalysis

Allegra Franchino

杜倫大學

Chloride abstraction to activate gold–chloride precatalysts is routinely performed employing silver(I) salts. However, they can be problematic due to light sensitivity, hygroscopicity, redox activity and interference with the desired gold chemistry, which would otherwise be water- and air-tolerant. Self-activating gold(I) chloride complexes have emerged as a promising alternative, but they still suffer from much lower activity and narrower applicability than Ag(I) salts.

In this talk, I will present a new class of self-activating phosphine Au(I) chloride complexes, featuring an anthracenyl bisurea as a quintuple H-bond donor. The best complex performs well in several intra- and intermolecular Au(I)-catalysed reactions, in the absence of any additive. Its catalytic activity is comparable to the one imparted by traditional inorganic chloride scavengers, such as sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate. Mechanistic studies shows that the exceptional H-bond donor ability of the bisurea unlocks access to a zwitterionic catalyst resting state where the Au–Cl bond has been cleaved, thus significantly reducing reaction barriers for catalysis. The principles uncovered by our work enable for the first time H-bond donors to compete with inorganic chloride scavengers in terms of activity and generality.

觀看方式

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直播鏈接：http://live.bilibili.com/23843035

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