第一條:潮氣量應該是保護性的
We suggest that in post-CA patients the VT should be set between 6 and 8 mL/kg PBW, in volume- or pressure-controlled ventilation but keeping in mind the interplay between VT and other parameters of MV (i.e., Pplat, ΔP, PEEP, MP) as well as hemodynamics. Assisted ventilation may be used according to clinical conditions and the level of sedation of the patient.
作者團隊建議在心跳驟停(CA)后,無論是容量還是壓力控制通氣,病人的潮氣量(VT)應該設置在6-8ml/kg理想體重,但切記VT與其他機械通氣(MV)參數間的相互影響,例如平臺壓(Pplat)、驅動壓(ΔP)、呼氣末正壓(PEEP)、機械能(MP),以及血流動力學。依據臨床情況與病人的鎮靜程度,或可使用輔助通氣模式。
第二條:平臺壓應該個體化
We suggest that in post-CA patients the Pplat should be kept equal or lower than 20 cmH2O and corrected for intra-abdominal pressure when clinically indicated. In obese patients or those with increased intra-abdominal pressure with Pplat>27 cmH2O, a simplified formula may help estimate the required correction of Pplat: Pplat target+(intra-abdominal pressure-13cmH2O)/2.
作者團隊建議CA后病人的平臺壓應該小于或等于20cmH2O;當有臨床指征,需要根據腹內壓進行校正。對于肥胖或那些腹內壓增加而平臺壓大于27cmH2O的病人,一條簡易的公式或有助于估計平臺壓所需的校正:目標平臺壓+(腹內壓-13cmH2O)/2。
第三條:呼氣末正壓要低一些,但必須足夠
We suggest that in post-CA patients a PEEP of 5 cmH2O should be initially used to reach a SatO2 at least above 92% and progressively increase in case of oxygen desaturation or worsening of respiratory mechanics.
作者團隊建議CA后就開始使用5cmH2O的PEEP使血氧飽和度(SatO2)至少在92%以上,如果SatO2下降,或呼吸力學惡化,可以逐漸增加。
第四條:關注驅動壓!
We suggest in post-CA patients to maintain a ΔP<13cmH2O optimizing the VT for the respective compliance of the respiratory system.
作者團隊建議CA后根據呼吸系統的順應性優化設置潮氣量,以維持ΔP<13cmH2O。
第五條:應以動脈pH值(pHa)與二氧化碳分壓(PaCO2)為目標調整呼吸頻率
We suggest that in post-CA patients, the respiratory rate should be kept in a range between 8 and 16 breaths/min.
作者團隊建議CA后,病人的呼吸頻率應保持在8~16次/分的范圍之內。
第六條:機械能是個引人注目的指標,但應謹慎
As per evidence to date, if assessed at the bedside, we suggest that in post-CA patients MP should be targeted as lower than 17 J/min, taking into account ΔP and respiratory rate.
按目前的證據,如果可以床旁評估,作者團隊建議在CA后,機械能應以<17焦/分鐘為目標,但要考慮到ΔP與呼吸頻率。
第七條:氧合必須精確地調整到正常范圍
According to the findings to date, a cutoff of PaO2 of 70–110mmHg seems reasonable in this patient population.
根據目前的發現,這類病人的PaO2的切點值設定在70~110mmHg看來是合理的。
第八條:目前來說,PaCO2應在正常范圍
The appropriate threshold to apply in post-CA patients is yet to be defined. According to the literature, a value of PaCO2 ranging between 35 and 50 mmHg seems to be preferable.
尚未確定適用于CA患者的合適的PaCO2閾值。根據文獻,35~50mmHg范圍內的數值看來是可取的。
第九條:體溫也可以影響通氣功能
In patients who remain comatose post-CA, the guidelines recommend continuous monitoring of core temperature and prevention of fever (defined as a temperature>37.7 °C) for at least 72 h. Evidence is insufficient to recommend for or against temperature control at 32–36 °C or early cooling after CA.
對于CA后仍然昏迷的病人,指南推薦至少72小時連續監測核心體溫并防止發熱(定義為體溫>37.7°C)。沒有充足的證據支持或反對體溫控制在32~36°C和CA后早期降溫。
第十條:血流動力學必須維持穩定
Patients with post-CA syndrome need to be strictly monitored for possible detrimental respiratory and cardiovascular interactions, thus accounting for targeted temperature management (around 36°C) and personalized cardiovascular targets.
CA后綜合征的病人可能出現呼吸系統與心血管系統的有害互動,必須嚴密監測,以應對目標體溫管理(36°C左右)和個體化的心血管系統目標。
出處:急重癥世界
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